Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer.

Differential Roles for DUSP Family Members in Epithelial-to-Mesenchymal Transition and Cancer Stem Cell Regulation in Breast Cancer.

Dual-specificity phosphatases (DUSPs) dephosphorylate threonine/serine and tyrosine residues on their substrates. Here we show that DUSP1, DUSP4, and DUSP6 are involved in epithelial-to-mesenchymal transition (EMT) and breast cancer stem cell (CSC) regulation. DUSP1, DUSP4, and DUSP6 are induced dur...

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Bibliographic Details
Main Authors: Tara Boulding, Fan Wu, Robert McCuaig, Jennifer Dunn, Christopher R Sutton, Kristine Hardy, Wenjuan Tu, Amanda Bullman, Desmond Yip, Jane E Dahlstrom, Sudha Rao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4747493?pdf=render

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http://europepmc.org/articles/PMC4747493?pdf=render

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