Effects of hypoglycemia on myocardial susceptibility to ischemia–reperfusion injury and preconditioning in hearts from rats with and without type 2 diabetes

Effects of hypoglycemia on myocardial susceptibility to ischemia–reperfusion injury and preconditioning in hearts from rats with and without type 2 diabetes

Abstract Background Hypoglycemia is associated with increased mortality rate in patients with diabetes. The underlying mechanisms may involve reduced myocardial tolerance to ischemia and reperfusion (IR) or reduced capacity for ischemic preconditioning (IPC). As IPC is associated with increased myoc...

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Bibliographic Details
Main Authors: Kim B. Pælestik, Nichlas R. Jespersen, Rebekka V. Jensen, Jacob Johnsen, Hans Erik Bøtker, Steen B. Kristiansen
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Cardiovascular Diabetology
Subjects:
Ischemia
Reperfusion
Infarct size
Glucose uptake
O-GlcNAc
Hypoglycemia
Online Access:http://link.springer.com/article/10.1186/s12933-017-0628-1

Internet

http://link.springer.com/article/10.1186/s12933-017-0628-1

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