Defective Interferon Gamma Production by Tumor-Specific CD8+ T Cells Is Associated With 5′Methylcytosine-Guanine Hypermethylation of Interferon Gamma Promoter

Defective Interferon Gamma Production by Tumor-Specific CD8+ T Cells Is Associated With 5′Methylcytosine-Guanine Hypermethylation of Interferon Gamma Promoter

Interferon gamma (IFNγ) supports effector responses of CD8+ cytotoxic T lymphocytes (CTLs) and is a surrogate marker for detection of antigen-specific T cells. Here, we show that tumor-specific CTL clones have impaired IFNγ expression and production upon activation. Assessment of the relationship be...

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Bibliographic Details
Main Authors: Megat Abd Hamid, Xuan Yao, Craig Waugh, Samara Rosendo-Machado, Chris Li, Timothy Rostron, John Frankland, Yanchun Peng, Tao Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Immunology
Subjects:
methylation
mRNA
interferon gamma
promoter
CD8+ T cells
response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00310/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00310/full

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