Combining use of captopril and losartan attenuates the progress of Streptococcus pneumoniae-induced tympanosclerosis through the suppression of TGF-β1 expression.

Combining use of captopril and losartan attenuates the progress of Streptococcus pneumoniae-induced tympanosclerosis through the suppression of TGF-β1 expression.

In this study, using an Streptococcus pneumoniae-induced tympanosclerosis (TS) model, we explored the effects of captopril and losartan in the treatment of TS and the possible mechanisms.A prospective experimental animal study.We set up the TS models in both guinea pig and wistar rat by inoculation...

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Bibliographic Details
Main Authors: Wenqing Yan, Jianfeng Li, Renjie Chai, Wentao Guo, Lei Xu, Yuechen Han, Xiaohui Bai, Haibo Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4216096?pdf=render

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http://europepmc.org/articles/PMC4216096?pdf=render

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