MicroRNA-183 attenuates osteoarthritic pain by inhibiting the TGFα-mediated CCL2/CCR2 signalling axis

MicroRNA-183 attenuates osteoarthritic pain by inhibiting the TGFα-mediated CCL2/CCR2 signalling axis

Aims: MicroRNA-183 (miR-183) is known to play important roles in osteoarthritis (OA) pain. The aims of this study were to explore the specific functions of miR-183 in OA pain and to investigate the underlying mechanisms. Methods: Clinical samples were collected from patients with OA, and a mouse mod...

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Bibliographic Details
Main Authors: Zirong Tao, Yang Zhou, Biyun Zeng, Xucheng Yang, Manman Su
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2021-08-01
Series:Bone & Joint Research
Subjects:
osteoarthritis pain
microrna-183
transforming growth factor α
c-c motif chemokine ligand 2
c-c chemokine receptor 2
inflammatory factor
c-c motif chemokine ligand 2 (ccl2)
micrornas (mirnas)
macrophages
osteoarthritis (oa)
quantitative polymerase chain reaction
destabilization of the medial meniscus (dmm)
sodium
cytokines
staining
il- 6
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.108.BJR-2019-0308.R2

Internet

https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.108.BJR-2019-0308.R2

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