Kaempherol and Luteolin Decrease Claudin-2 Expression Mediated by Inhibition of STAT3 in Lung Adenocarcinoma A549 Cells

Kaempherol and Luteolin Decrease Claudin-2 Expression Mediated by Inhibition of STAT3 in Lung Adenocarcinoma A549 Cells

Claudin-2 is highly expressed in human lung adenocarcinoma tissues and may be a novel target for cancer chemotherapy because knockdown of claudin-2 decreases cell proliferation. We found that flavonoids including kaempferol, chrysin, and luteolin concentration-dependently decrease claudin-2 expressi...

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Bibliographic Details
Main Authors: Hiroyuki Sonoki, Asami Tanimae, Satoshi Endo, Toshiyuki Matsunaga, Takumi Furuta, Kenji Ichihara, Akira Ikari
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Nutrients
Subjects:
lung adenocarcinoma
claudin-2
kaempferol
chrysin
STAT3
Online Access:http://www.mdpi.com/2072-6643/9/6/597

Internet

http://www.mdpi.com/2072-6643/9/6/597

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