The Effector Domain Region of the Vibrio vulnificus MARTX Toxin Confers Biphasic Epithelial Barrier Disruption and Is Essential for Systemic Spread from the Intestine.

The Effector Domain Region of the Vibrio vulnificus MARTX Toxin Confers Biphasic Epithelial Barrier Disruption and Is Essential for Systemic Spread from the Intestine.

Vibrio vulnificus causes highly lethal bacterial infections in which the Multifunctional Autoprocessing Repeats-in-Toxins (MARTX) toxin product of the rtxA1 gene is a key virulence factor. MARTX toxins are secreted proteins up to 5208 amino acids in size. Conserved MARTX N- and C-terminal repeat reg...

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Bibliographic Details
Main Authors: Hannah E Gavin, Nike T Beubier, Karla J F Satchell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5218395?pdf=render

Internet

http://europepmc.org/articles/PMC5218395?pdf=render

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