Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: An in vivo [(11)C](R)-PK11195-PET pilot study

Microglia activation in multiple sclerosis black holes predicts outcome in progressive patients: An in vivo [(11)C](R)-PK11195-PET pilot study

The pathophysiological correlates and the contribution to persisting disability of hypointense T1-weighted MRI lesions, black holes (BH), in multiple sclerosis (MS) are still unclear. In order to study the in vivo functional correlates of this MRI finding, we used 11C-PK11195 PET (PK-PET) to investi...

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Bibliographic Details
Main Authors: Paolo Giannetti, Marios Politis, Paul Su, Federico Turkheimer, Omar Malik, Shiva Keihaninejad, Kit Wu, Richard Reynolds, Richard Nicholas, Paola Piccini
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Neurobiology of Disease
Subjects:
Multiple sclerosis
Black holes
Microglia
Neurodegeneration
PK11195-PET
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000321

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http://www.sciencedirect.com/science/article/pii/S0969996114000321

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