The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis.

The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis.

Viral hepatitis, obesity, and alcoholism all represent major risk factors for hepatocellular carcinoma (HCC). Although these conditions also lead to integrated stress response (ISR) or unfolded protein response (UPR) activation, the extent to which these stress pathways influence the pathogenesis of...

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Bibliographic Details
Main Authors: Diane DeZwaan-McCabe, Jesse D Riordan, Angela M Arensdorf, Michael S Icardi, Adam J Dupuy, D Thomas Rutkowski
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3868529?pdf=render

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http://europepmc.org/articles/PMC3868529?pdf=render

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