GSK-3 Beta Does Not Stabilize Cryptochrome in the Circadian Clock of Drosophila.

Cryptochrome (CRY) is the primary photoreceptor of Drosophila's circadian clock. It resets the circadian clock by promoting light-induced degradation of the clock protein Timeless (TIM) in the proteasome. Under constant light, the clock stops because TIM is absent, and the flies become arrhythm...

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Bibliographic Details
Main Authors: Robin Fischer, Charlotte Helfrich-Förster, Nicolai Peschel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4704813?pdf=render