Anti-CD20 treatment effectively attenuates cortical pathology in a rat model of widespread cortical demyelination

Abstract Background Cortical demyelination represents a prominent feature of the multiple sclerosis (MS) brain, especially in (late) progressive stages. We recently developed a new rat model that reassembles critical features of cortical pathology characteristic to progressive types of MS. In person...

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Bibliographic Details
Main Authors: Michaela T. Haindl, Muammer Üçal, Benjamin Klaus, Lennart Tögl, Jana Dohrmann, Milena Z. Adzemovic, Christian Enzinger, Sonja Hochmeister
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Neuroinflammation
Subjects:
Online Access:https://doi.org/10.1186/s12974-021-02189-w