Simvastatin does not alleviate muscle pathology in a mouse model of Duchenne muscular dystrophy

Simvastatin does not alleviate muscle pathology in a mouse model of Duchenne muscular dystrophy

Abstract Background Duchenne muscular dystrophy (DMD) is an incurable disease, caused by the mutations in the DMD gene, encoding dystrophin, an actin-binding cytoskeletal protein. Lack of functional dystrophin results in muscle weakness, degeneration, and as an outcome cardiac and respiratory failur...

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Bibliographic Details
Main Authors: Olga Mucha, Paulina Podkalicka, Katarzyna Kaziród, Emilia Samborowska, Józef Dulak, Agnieszka Łoboda
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Skeletal Muscle
Subjects:
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors
Simvastatin
DMD
Duchenne muscular dystrophy
Angiogenesis
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Online Access:https://doi.org/10.1186/s13395-021-00276-3

Internet

https://doi.org/10.1186/s13395-021-00276-3

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