Arylcinnamido-propionone conjugates as tubulin polymerization inhibitors and apoptotic inducers
A series of cinnamido-propionone conjugates (4–6a-h and 7a-f) has been designed, synthesized and evaluated for their anticancer potential against some human cancer cell lines. Among them, conjugates 6d and 6g have shown significant cytotoxic activity against prostate cancer cells (DU-145) displaying...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-12-01
|
| Series: | Arabian Journal of Chemistry |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535216301125 |