Mitochondrial common deletion, a potential biomarker for cancer occurrence, is selected against in cancer background: a meta-analysis of 38 studies.

Mitochondrial common deletion, a potential biomarker for cancer occurrence, is selected against in cancer background: a meta-analysis of 38 studies.

Mitochondrial dysfunction has been long proposed to play a major role in tumorigenesis. Mitochondrial DNA (mtDNA) mutations, especially the mtDNA 4,977 bp deletion has been found in patients of various types of cancer. In order to comprehend the mtDNA 4,977 bp deletion status in various cancer types...

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Bibliographic Details
Main Authors: Hezhongrong Nie, Hongying Shu, Rasika Vartak, Amanda Claire Milstein, Yalin Mo, Xiaoqin Hu, Hezhi Fang, Lijun Shen, Zhinan Ding, Jianxin Lu, Yidong Bai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3701633?pdf=render

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http://europepmc.org/articles/PMC3701633?pdf=render

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