Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC

Mammary Stem Cell Self-Renewal Is Regulated by Slit2/Robo1 Signaling through SNAI1 and mINSC

Tissue homeostasis requires somatic stem cell maintenance; however, mechanisms regulating this process during organogenesis are not well understood. Here, we identify asymmetrically renewing basal and luminal stem cells in the mammary end bud. We demonstrate that SLIT2/ROBO1 signaling regulates the...

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Bibliographic Details
Main Authors: Mimmi S. Ballard, Anna Zhu, Naomi Iwai, Michael Stensrud, Aurelia Mapps, Maira Pia Postiglione, Juergen A. Knoblich, Lindsay Hinck
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Cell Reports
Subjects:
breast
SLIT
ROBO
asymmetric cell division
Inscuteable
SNAIL
mammary stem cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715010177

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http://www.sciencedirect.com/science/article/pii/S2211124715010177

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