Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin

Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin

Two new and improved procedures were developed for the synthesis of 1-(1-naphthyloxy)-2,3-epoxypropane as an important intermediate in the production of the beta-blocker and antioxidant, 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)-2-propanol (propranolol). Both base homogeneous and heterogeneous PTC...

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Bibliographic Details
Main Authors: SLOBODANKA JOVANOVIC, MILANKA VICO-STEVANOVIC, DRAGANA UGLJESIC-KILIBARDA, DRAGICA POPADIC, SLOBODANKA SIMIC, DIJAMANDA DZELETOVIC
Format: Article
Language:English
Published: Serbian Chemical Society 2006-09-01
Series:Journal of the Serbian Chemical Society
Subjects:
heterogeneous PTC catalysis
base homogeneous catalysis
selectivity
yield
model system
Online Access:http://www.shd.org.yu/HtDocs/SHD/Vol71/No8-9/JSCS_V71_No8-9-03.pdf
Description
Summary:Two new and improved procedures were developed for the synthesis of 1-(1-naphthyloxy)-2,3-epoxypropane as an important intermediate in the production of the beta-blocker and antioxidant, 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)-2-propanol (propranolol). Both base homogeneous and heterogeneous PTC catalysis were employed. High yields and remarkable selectivity were achieved. The improved purity is particularly important, in view of the quality requirements for propranolol hydrochloride as an active pharmaceutical ingredient.
ISSN:0352-5139

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