Catalysis in the alkylation reaction of 1-naphthol with epichlorohydrin

Two new and improved procedures were developed for the synthesis of 1-(1-naphthyloxy)-2,3-epoxypropane as an important intermediate in the production of the beta-blocker and antioxidant, 1-[(1-methylethyl)amino]-3-(1-naphthyloxy)-2-propanol (propranolol). Both base homogeneous and heterogeneous PTC...

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Main Authors: SLOBODANKA JOVANOVIC, MILANKA VICO-STEVANOVIC, DRAGANA UGLJESIC-KILIBARDA, DRAGICA POPADIC, SLOBODANKA SIMIC, DIJAMANDA DZELETOVIC
Format: Article
Language:English
Published: Serbian Chemical Society 2006-09-01
Series:Journal of the Serbian Chemical Society
Subjects:
Online Access:http://www.shd.org.yu/HtDocs/SHD/Vol71/No8-9/JSCS_V71_No8-9-03.pdf