Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration.

Selective CNS Uptake of the GCP-II Inhibitor 2-PMPA following Intranasal Administration.

Glutamate carboxypeptidase II (GCP-II) is a brain metallopeptidase that hydrolyzes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to NAA and glutamate. Small molecule GCP-II inhibitors increase brain NAAG, which activates mGluR3, decreases glutamate, and provide therapeutic utility in...

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Bibliographic Details
Main Authors: Rana Rais, Krystyna Wozniak, Ying Wu, Minae Niwa, Marigo Stathis, Jesse Alt, Marc Giroux, Akira Sawa, Camilo Rojas, Barbara S Slusher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4494705?pdf=render

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http://europepmc.org/articles/PMC4494705?pdf=render

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