H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant

H3F3A mutant allele specific imbalance in an aggressive subtype of diffuse midline glioma, H3 K27M-mutant

Abstract Diffuse midline glioma, H3 K27M-mutant is a lethal brain tumor located in the thalamus, brain stem, or spinal cord. H3 K27M encoded by the mutation of a histone H3 gene such as H3F3A plays a pivotal role in the tumorigenesis of this type of glioma. Although several studies have revealed com...

Full description

Bibliographic Details
Main Authors: Sachi Maeda, Fumiharu Ohka, Yusuke Okuno, Kosuke Aoki, Kazuya Motomura, Kazuhito Takeuchi, Hironao Kusakari, Nobuyuki Yanagisawa, Shinya Sato, Junya Yamaguchi, Kuniaki Tanahashi, Masaki Hirano, Akira Kato, Hiroyuki Shimizu, Yotaro Kitano, Shintaro Yamazaki, Shinji Yamashita, Hideo Takeshima, Keiko Shinjo, Yutaka Kondo, Toshihiko Wakabayashi, Atsushi Natsume
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Acta Neuropathologica Communications
Subjects:
Diffuse midline glioma
H3 K27M-mutant
Mutant allele specific imbalance
Whole-genome sequencing
Droplet digital polymerase chain reaction
Online Access:https://doi.org/10.1186/s40478-020-0882-4

Internet

https://doi.org/10.1186/s40478-020-0882-4

Similar Items