Blood flow controls bone vascular function and osteogenesis

Blood flow controls bone vascular function and osteogenesis

Formation of new blood vessels and bone is coupled. Here the authors show that blood flow represents a key regulator of angiogenesis and endothelial Notch signalling in the bone, and that reactivation of Notch signalling in the endothelium of aged mice rejuvenates the bone.

Bibliographic Details
Main Authors: Saravana K. Ramasamy, Anjali P. Kusumbe, Maria Schiller, Dagmar Zeuschner, M. Gabriele Bixel, Carlo Milia, Jaba Gamrekelashvili, Anne Limbourg, Alexander Medvinsky, Massimo M. Santoro, Florian P. Limbourg, Ralf H. Adams
Format: Article
Language:English
Published: Nature Publishing Group 2016-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13601

Internet

https://doi.org/10.1038/ncomms13601

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