The Role of Glucocorticoid Receptor and Oxytocin Receptor in the Septic Heart in a Clinically Relevant, Resuscitated Porcine Model With Underlying Atherosclerosis

The Role of Glucocorticoid Receptor and Oxytocin Receptor in the Septic Heart in a Clinically Relevant, Resuscitated Porcine Model With Underlying Atherosclerosis

The pathophysiology of sepsis-induced myocardial dysfunction is not resolved to date and comprises inflammation, barrier dysfunction and oxidative stress. Disease-associated reduction of tissue cystathionine-γ-lyase (CSE) expression, an endogenous H2S-producing enzyme, is associated with oxidative s...

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Bibliographic Details
Main Authors: Tamara Merz, Nicole Denoix, Daniela Wigger, Christiane Waller, Martin Wepler, Sabine Vettorazzi, Jan Tuckermann, Peter Radermacher, Oscar McCook
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Endocrinology
Subjects:
sepsis
heart
oxytocin receptor
glucocorticoid receptor
cystathionine-γ-lyase
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2020.00299/full

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https://www.frontiersin.org/article/10.3389/fendo.2020.00299/full

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