Structural Characterization of Non-structural Protein 9 Complexed With Specific Nanobody Pinpoints Two Important Residues Involved in Porcine Reproductive and Respiratory Syndrome Virus Replication

Structural Characterization of Non-structural Protein 9 Complexed With Specific Nanobody Pinpoints Two Important Residues Involved in Porcine Reproductive and Respiratory Syndrome Virus Replication

Porcine reproductive and respiratory syndrome (PRRS), caused by PRRS virus (PRRSV), is a widespread viral disease that has led to huge economic losses for the global swine industry. Non-structural protein 9 (Nsp9) of PRRSV possesses essential RNA-dependent RNA polymerase (RdRp) activity for viral RN...

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Bibliographic Details
Main Authors: Yan Wang, Rui Li, Songlin Qiao, Jiaxi Wang, Hongliang Liu, Zhijun Li, Hongfang Ma, Lei Yang, Haiyu Ruan, Maoyang Weng, Julian A. Hiscox, James P. Stewart, Yuchen Nan, Gaiping Zhang, En-Min Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Microbiology
Subjects:
PRRSV
Nsp9
RdRp
nanobody
SAXS
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.581856/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2020.581856/full

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