Aβ-40 Y10F Increases βfibrils Formation but Attenuates the Neurotoxicity of Amyloid-β Peptide

Aβ-40 Y10F Increases βfibrils Formation but Attenuates the Neurotoxicity of Amyloid-β Peptide

Alzheimer’s disease (AD) is characterized by the abnormal aggregation of amyloid-β peptide (Aβ) in extracellular deposits known as senile plaques. The tyrosine residue (Tyr-10) is believed to be important in Aβ-induced neurotoxicity due to the formation of tyrosyl radicals. To reduce the likelihood...

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Bibliographic Details
Main Authors: Zhaofeng Jiang, Shigong Zhu, Yaxuan Sun, Ke Xu, Ping Chang, Wenjuan Liu, Xueling Dai
Format: Article
Language:English
Published: MDPI AG 2012-04-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
amyloid-β peptide
βfibrils
neurotoxicity
Online Access:http://www.mdpi.com/1422-0067/13/5/5324

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http://www.mdpi.com/1422-0067/13/5/5324

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