Comparison of systemic and mucosal immunization with helper-dependent adenoviruses for vaccination against mucosal challenge with SHIV.

Comparison of systemic and mucosal immunization with helper-dependent adenoviruses for vaccination against mucosal challenge with SHIV.

Most HIV-1 infections are thought to occur at mucosal surfaces during sexual contact. It has been hypothesized that vaccines delivered at mucosal surfaces may mediate better protection against HIV-1 than vaccines that are delivered systemically. To test this, rhesus macaques were vaccinated by intra...

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Bibliographic Details
Main Authors: Eric A Weaver, Pramod N Nehete, Bharti P Nehete, Guojun Yang, Stephanie J Buchl, Patrick W Hanley, Donna Palmer, David C Montefiori, Guido Ferrari, Philip Ng, K Jagannadha Sastry, Michael A Barry
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3701068?pdf=render

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http://europepmc.org/articles/PMC3701068?pdf=render

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