Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development

Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development

A critical barrier in the treatment of endosomal and lysosomal diseases is the lack of understanding of the in vivo functions of the putative causative genes. We addressed this by investigating a key pair of endocytic adaptor proteins, PH domain-containing endocytic trafficking adaptor 1 and 2 (PHET...

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Bibliographic Details
Main Authors: Kristin M. Ates, Tong Wang, Trevor Moreland, Rajalakshmi Veeranan-Karmegam, Manxiu Ma, Chelsi Jeter, Priya Anand, Wolfgang Wenzel, Hyung-Goo Kim, Lynne A. Wolfe, Joshi Stephen, David R. Adams, Thomas Markello, Cynthia J. Tifft, Robert Settlage, William A. Gahl, Graydon B. Gonsalvez, May Christine Malicdan, Heather Flanagan-Steet, Y. Albert Pan
Format: Article
Language:English
Published: The Company of Biologists 2020-05-01
Series:Disease Models & Mechanisms
Subjects:
pheta1
ipip27a
ocrl
endocytosis
undiagnosed disease
Online Access:http://dmm.biologists.org/content/13/5/dmm041913

Internet

http://dmm.biologists.org/content/13/5/dmm041913

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