Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates

Selective Inhibition of 2-Oxoglutarate and 2-Oxoadipate Dehydrogenases by the Phosphonate Analogs of Their 2-Oxo Acid Substrates

Phosphonate analogs of pyruvate and 2-oxoglutarate are established specific inhibitors of cognate 2-oxo acid dehydrogenases. The present work develops application of this class of compounds to specific in vivo inhibition of 2-oxoglutarate dehydrogenase (OGDH) and its isoenzyme, 2-oxoadipate dehydrog...

Full description

Bibliographic Details
Main Authors: Artem V. Artiukhov, Alexey V. Kazantsev, Nikolay V. Lukashev, Marco Bellinzoni, Victoria I. Bunik
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Chemistry
Subjects:
succinyl phosphonate
glutaryl phosphonate
adipoyl phosphonate
OGDH
OADH
DHTKD1
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2020.596187/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2020.596187/full

Similar Items