Exploring the interaction between epidermal growth factor receptor tyrosine kinase and some of the synthesized inhibitors using combination of in-silico and in-vitro cytotoxicity methods

Exploring the interaction between epidermal growth factor receptor tyrosine kinase and some of the synthesized inhibitors using combination of in-silico and in-vitro cytotoxicity methods

Quinazoline derivatives are potent inhibitors of human epidermal growth factor receptor (EGFR) as anticancer agents. In this study, the cytotoxic effects of a new series of synthesized quinazoline derivatives were evaluated using MTT assay against MCF-7 and HT-29 cell lines. Using molecular docking,...

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Bibliographic Details
Main Authors: Rezvan Rezaee Nasab, Mahboubeh Mansourian, Farshid Hassanzadeh, Mohsen Shahlaei
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2018-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
4-anilinoquinazoline; egfr; molecular docking; molecular dynamics simulation; 4(3h)-quinazolinones
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2018;volume=13;issue=6;spage=509;epage=522;aulast=Nasab

Internet

http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2018;volume=13;issue=6;spage=509;epage=522;aulast=Nasab

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