High BMPR2 expression leads to enhanced SMAD1/5/8 signalling and GDF6 responsiveness in human adipose-derived stem cells: implications for stem cell therapies for intervertebral disc degeneration

High BMPR2 expression leads to enhanced SMAD1/5/8 signalling and GDF6 responsiveness in human adipose-derived stem cells: implications for stem cell therapies for intervertebral disc degeneration

Stem cell–based regenerative strategies are promising for intervertebral disc degeneration. Stimulation of bone-marrow- and adipose-derived multipotent stem cells with recombinant human growth differentiation factor 6 (rhGDF6) promotes anabolic nucleus pulposus like phenotypes. In comparison to mese...

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Bibliographic Details
Main Authors: Tom Hodgkinson, Francis Wignall, Judith A Hoyland, Stephen M Richardson
Format: Article
Language:English
Published: SAGE Publishing 2020-05-01
Series:Journal of Tissue Engineering
Online Access:https://doi.org/10.1177/2041731420919334

Internet

https://doi.org/10.1177/2041731420919334

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