Granulocyte-Colony Stimulating Factor Increases Cerebral Blood Flow via a NO Surge Mediated by Akt/eNOS Pathway to Reduce Ischemic Injury

Granulocyte-colony stimulating factor (G-CSF) protects brain from ischemic/reperfusion (I/R) injury, and inhibition of nitric oxide (NO) synthases partially reduces G-CSF protection. We thus further investigated the effects of G-CSF on ischemia-induced NO production and its consequence on regional c...

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Bibliographic Details
Main Authors: Hock-Kean Liew, Jon-Son Kuo, Jia-Yi Wang, Cheng-Yoong Pang
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:The Scientific World Journal
Online Access:http://dx.doi.org/10.1155/2015/657932