Characterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profiling.

Characterization of CD8+ T cell differentiation following SIVΔnef vaccination by transcription factor expression profiling.

The onset of protective immunity against pathogenic SIV challenge in SIVΔnef-vaccinated macaques is delayed for 15-20 weeks, a process that is related to qualitative changes in CD8+ T cell responses induced by SIVΔnef. As a novel approach to characterize cell differentiation following vaccination, w...

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Bibliographic Details
Main Authors: James M Billingsley, Premeela A Rajakumar, Michelle A Connole, Nadine C Salisch, Sama Adnan, Yury V Kuzmichev, Henoch S Hong, R Keith Reeves, Hyung-joo Kang, Wenjun Li, Qingsheng Li, Ashley T Haase, R Paul Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-03-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4358830?pdf=render

Internet

http://europepmc.org/articles/PMC4358830?pdf=render

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