Epigenetic Targeting of Autophagy via HDAC Inhibition in Tumor Cells: Role of p53

Tumor development and progression is the consequence of genetic as well as epigenetic alterations of the cell. As part of the epigenetic regulatory system, histone acetyltransferases (HATs) and deacetylases (HDACs) drive the modification of histone as well as non-histone proteins. Derailed acetylati...

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Bibliographic Details
Main Authors: Maria Mrakovcic, Lauren Bohner, Marcel Hanisch, Leopold F. Fröhlich
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Molecular Sciences
Subjects:
p53
Online Access:https://www.mdpi.com/1422-0067/19/12/3952