Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis.

Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis.

Pulmonary fibrosis is often triggered by an epithelial injury resulting in the formation of fibrotic lesions in the lung, which progress to impair gas exchange and ultimately cause death. Recent clinical trials using drugs that target either inflammation or a specific molecule have failed, suggestin...

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Bibliographic Details
Main Authors: Satish K Madala, Ramakrishna Edukulla, Mukta Phatak, Stephanie Schmidt, Cynthia Davidson, Thomas H Acciani, Thomas R Korfhagen, Mario Medvedovic, Timothy D Lecras, Kimberly Wagner, William D Hardie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3903543?pdf=render

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http://europepmc.org/articles/PMC3903543?pdf=render

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