The effect of high fat diet and metformin treatment on liver lipids accumulation and their impact on insulin action

Abstract We sought to determine whether metformin treatment reverses a high-fat diet (HFD)-induced hepatic insulin resistance (IRes) and to identify lipid intermediates involved in induction of liver IRes. The experiments were conducted on male Wistar rats divided into three groups: 1. Control, 2. f...

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Bibliographic Details
Main Authors: Piotr Zabielski, Hady Razak Hady, Marta Chacinska, Kamila Roszczyc, Jan Gorski, Agnieszka U. Blachnio-Zabielska
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-25397-6