Development of spray-dried amorphous solid dispersions of tadalafil using glycyrrhizin for enhanced dissolution and aphrodisiac activity in male rats

Development of spray-dried amorphous solid dispersions of tadalafil using glycyrrhizin for enhanced dissolution and aphrodisiac activity in male rats

Tadalafil (TDL) is a phosphodiesterase-5 inhibitor (PDE5I), indicated for erectile dysfunction (ED). However, TDL exhibits poor aqueous solubility and dissolution rate, which may limit its application. This study aims to prepare amorphous solid dispersion (ASD) by spray-drying, using glycyrrhizin-a...

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Bibliographic Details
Main Authors: Mohammed Muqtader Ahmed, Farhat Fatima, Mohd Abul Kalam, Aws Alshamsan, Gamal A. Soliman, Abdul Azim Shaikh, Saad M Alshahrani, Mohammed F. Aldawsari, Saurabh Bhatia, Md. Khalid Anwer
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Saudi Pharmaceutical Journal
Subjects:
Spray-drying
Dissolution enhancement
Stability study
Aphrodisiac activity
Online Access:http://www.sciencedirect.com/science/article/pii/S131901642030267X

Internet

http://www.sciencedirect.com/science/article/pii/S131901642030267X

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