Dithiocarbamate as a Valuable Scaffold for the Inhibition of Metallo-β-Lactmases

Dithiocarbamate as a Valuable Scaffold for the Inhibition of Metallo-β-Lactmases

The ‘superbug’ infection caused by metallo-β-lactamases (MβLs) has grown into an emergent health threat. Given the clinical importance of MβLs, a novel scaffold, dithiocarbamate, was constructed. The obtained molecules, DC1, DC8 and DC10, inhibited M&am...

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Bibliographic Details
Main Authors: Ying Ge, Li-Wei Xu, Ya Liu, Le-Yun Sun, Han Gao, Jia-Qi Li, Kewu Yang
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Biomolecules
Subjects:
antibiotic resistance
metallo-β-lactamase
inhibitor
dithiocarbamate
activity assay
Online Access:https://www.mdpi.com/2218-273X/9/11/699

Internet

https://www.mdpi.com/2218-273X/9/11/699

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