Kinetic interpretation of log-logistic dose-time response curves

Abstract A Hill-type time-response curve was derived using a single-step chemical kinetics approximation. The rate expression for the transformation is a differential equation that provides an interpolation formula between the logistic growth curve and second order kinetics. The solution is equivale...

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Bibliographic Details
Main Authors: Walter W. Focke, Isbe van der Westhuizen, Ndeke Musee, Mattheüs Theodor Loots
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-02474-w