Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling.

Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling.

There is accumulating evidence that dysregulated JAK signaling occurs in a wide variety of cancer types. In particular, mutations in JAK2 can result in the constitutive activation of STAT transcription factors and lead to oncogenic growth. JAK kinases are established Hsp90 client proteins and here w...

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Bibliographic Details
Main Authors: David A Proia, Kevin P Foley, Tim Korbut, Jim Sang, Don Smith, Richard C Bates, Yuan Liu, Alex F Rosenberg, Dan Zhou, Keizo Koya, James Barsoum, Ronald K Blackman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3077378?pdf=render

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http://europepmc.org/articles/PMC3077378?pdf=render

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