Investigation of Cervical Tumor Biopsies for Chromosomal Loss of Heterozygosity (LOH) and Microsatellite Instability (MSI) at the HLA II Locus in HIV-1/HPV Co-infected Women

Investigation of Cervical Tumor Biopsies for Chromosomal Loss of Heterozygosity (LOH) and Microsatellite Instability (MSI) at the HLA II Locus in HIV-1/HPV Co-infected Women

Background: A subgroup of women who are co-infected with human immunodeficiency virus type 1 (HIV-1) and human papillomavirus (HPV) progress rapidly to cervical disease regardless of high CD4 counts. Chromosomal loss of heterozygosity (LOH) and microsatellite instability (MSI) are early frequent gen...

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Bibliographic Details
Main Authors: Ramadhani Chambuso, Evelyn Kaambo, Lynette Denny, Clive M. Gray, Anna-Lise Williamson, Monika Migdalska-Sęk, Gloudi Agenbag, George Rebello, Raj Ramesar
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
cervical cancer
loss of heterozygosity
microsatellite instability
HLA II locus
HIV-1/HPV co-infection
host molecular genetics
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00951/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.00951/full

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