Plasma Membrane Na+-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy

Plasma Membrane Na+-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy

SLC13A5 is a Na+-coupled transporter for citrate that is expressed in the plasma membrane of specific cell types in the liver, testis, and brain. It is an electrogenic transporter with a Na+:citrate3− stoichiometry of 4:1. In humans, the Michaelis constant for SLC13A5 to transport citrate is ~600 μM...

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Bibliographic Details
Main Authors:	Yangzom D. Bhutia, Jonathan J. Kopel, John J. Lawrence, Volker Neugebauer, Vadivel Ganapathy
Format:	Article
Language:	English
Published:	MDPI AG 2017-02-01
Series:	Molecules
Subjects:	citrate transporter NaCT (SLC13A5) CIC (SLC25A1) cytoplasmic citrate mitochondrial citrate GABA neurotransmitters fatty acid synthesis cholesterol synthesis tricarboxylic acid cycle NMDA receptor zinc
Online Access:	http://www.mdpi.com/1420-3049/22/3/378

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