Plasma Membrane Na+-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy

Plasma Membrane Na+-Coupled Citrate Transporter (SLC13A5) and Neonatal Epileptic Encephalopathy

SLC13A5 is a Na+-coupled transporter for citrate that is expressed in the plasma membrane of specific cell types in the liver, testis, and brain. It is an electrogenic transporter with a Na+:citrate3− stoichiometry of 4:1. In humans, the Michaelis constant for SLC13A5 to transport citrate is ~600 μM...

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Bibliographic Details
Main Authors: Yangzom D. Bhutia, Jonathan J. Kopel, John J. Lawrence, Volker Neugebauer, Vadivel Ganapathy
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Molecules
Subjects:
citrate transporter
NaCT (SLC13A5)
CIC (SLC25A1)
cytoplasmic citrate
mitochondrial citrate
GABA
neurotransmitters
fatty acid synthesis
cholesterol synthesis
tricarboxylic acid cycle
NMDA receptor
zinc
Online Access:http://www.mdpi.com/1420-3049/22/3/378

Internet

http://www.mdpi.com/1420-3049/22/3/378

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