Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss[S]

Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss[S]

The phosphodiesterase inhibitor (PDEI)/eNOS enhancer KMUP-1, targeting G-protein coupled receptors (GPCRs), improves dyslipidemia. We compared its lipid-lowering effects with simvastatin and explored hormone-sensitive lipase (HSL) translocation in hepatic fat loss. KMUP-1 HCl (1, 2.5, and 5 mg/kg/da...

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Bibliographic Details
Main Authors: Kung-Kai Kuo, Bin-Nan Wu, Chung-Pin Liu, Tzu-Yang Yang, Li-Pin Kao, Jiunn-Ren Wu, Wen-Ter Lai, Ing-Jun Chen
Format: Article
Language:English
Published: Elsevier 2015-11-01
Series:Journal of Lipid Research
Subjects:
low density lipoprotein/high density lipoprotein
scavenger receptor class B type I/peroxisome proliferator activated receptor γ
protein kinase A/G
3-hydroxy-3-methylglutaryl-CoA reductase
endothelial nitric-oxide synthase/RhoA/Rho kinase II
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520354766

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http://www.sciencedirect.com/science/article/pii/S0022227520354766

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