Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3.

Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3.

Toll-like Receptor 3 (TLR3) detects double-stranded (ds) RNAs to activate innate immune responses. While poly(I:C) is an excellent agonist for TLR3 in several cell lines and in human peripheral blood mononuclear cells, viral dsRNAs tend to be poor agonists, leading to the hypothesis that additional...

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Bibliographic Details
Main Authors: Yvonne Lai, Guanghui Yi, Alice Chen, Kanchan Bhardwaj, Brady J Tragesser, Rodrigo A Valverde, Adam Zlotnick, Suchetana Mukhopadhyay, C T Ranjith-Kumar, C Cheng Kao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3189932?pdf=render

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http://europepmc.org/articles/PMC3189932?pdf=render

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