miR-448 targets IDO1 and regulates CD8+ T cell response in human colon cancer

miR-448 targets IDO1 and regulates CD8+ T cell response in human colon cancer

Abstract Background Indoleamine 2,3-dioxygenase 1 (IDO1) is a critical regulator of T cell function, contributing to immune tolerance. Upregulation of IDO1 has been found in many cancer types; however, the regulatory mechanisms and clinical significance of IDO1 in colon cancer are still unclear. Her...

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Bibliographic Details
Main Authors: Qiong Lou, Ruixian Liu, Xiangling Yang, Weiqian Li, Lanlan Huang, Lili Wei, Huiliu Tan, Nanlin Xiang, Kawo Chan, Junxiong Chen, Huanliang Liu
Format: Article
Language:English
Published: BMJ Publishing Group 2019-08-01
Series:Journal for ImmunoTherapy of Cancer
Subjects:
IDO1
miR-448
CD8
Colon cancer
Immunology
Tumor microenvironment
Online Access:http://link.springer.com/article/10.1186/s40425-019-0691-0

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http://link.springer.com/article/10.1186/s40425-019-0691-0

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