Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis

Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis

The NLRP3 inflammasome is central to a variety of inflammatory diseases, but how it is regulated to prevent excessive inflammation is not clear. Here the authors show that NLRP3 activation causes SHP2 translocation to the mitochondria to interact with and dephosphorylate ANT1, thus stabilizing the m...

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Bibliographic Details
Main Authors: Wenjie Guo, Wen Liu, Zhen Chen, Yanhong Gu, Shuang Peng, Lihong Shen, Yan Shen, Xingqi Wang, Gen-Sheng Feng, Yang Sun, Qiang Xu
Format: Article
Language:English
Published: Nature Publishing Group 2017-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-02351-0

Internet

https://doi.org/10.1038/s41467-017-02351-0

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