TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells

TGF-β Signaling Accelerates Senescence of Human Bone-Derived CD271 and SSEA-4 Double-Positive Mesenchymal Stromal Cells

Summary: It is generally thought that the proliferative capacity and differentiation potential of somatic stem cells, including mesenchymal stromal/stem cells (MSCs) and hematopoietic stem cells, decline with age. We investigated the effects of aging on human bone-derived MSCs expressing CD271 and S...

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Bibliographic Details
Main Authors: Hiroshi Kawamura, Ryusuke Nakatsuka, Yoshikazu Matsuoka, Keisuke Sumide, Tatsuya Fujioka, Hiroaki Asano, Hirokazu Iida, Yoshiaki Sonoda
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671118300560

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http://www.sciencedirect.com/science/article/pii/S2213671118300560

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