Reversal of drug resistance by JS-K and nitric oxide in ABCB1- and ABCG2-expressing multi-drug resistant human tumor cells

Reversal of drug resistance by JS-K and nitric oxide in ABCB1- and ABCG2-expressing multi-drug resistant human tumor cells

Development of resistance to chemotherapy drugs is a significant problem in treating human malignancies in the clinic. Overexpression of ABC transporter proteins, including P-170 glycoprotein (P-gp), and breast cancer resistance protein (BCRP, ABCG2) have been implicated in this multi-drug resistanc...

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Bibliographic Details
Main Authors: Birandra K. Sinha, Lalith Perera, Ronald E. Cannon
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Nitric oxide
P-gp protein
Breast cancer resistance protein
Adriamycin
Mitoxantrone
Topotecan
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219331464

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http://www.sciencedirect.com/science/article/pii/S0753332219331464

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