Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease

Equilibrative nucleoside transporter ENT1 as a biomarker of Huntington disease

The initial goal of this study was to investigate alterations in adenosine A2A receptor (A2AR) density or function in a rat model of Huntington disease (HD) with reported insensitivity to an A2AR antagonist. Unsuspected negative results led to the hypothesis of a low striatal adenosine tone and to t...

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Bibliographic Details
Main Authors: Xavier Guitart, Jordi Bonaventura, William Rea, Marco Orrú, Lucrezia Cellai, Ilaria Dettori, Felicita Pedata, Marc Brugarolas, Antonio Cortés, Vicent Casadó, Ching-Pang Chang, Manikandan Narayanan, Yijuang Chern, Sergi Ferré
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
Adenosine
ENT1
A2A receptor
Huntington disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302054

Internet

http://www.sciencedirect.com/science/article/pii/S0969996116302054

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