Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways.

Under most experimental conditions, the activities of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA reductase) and cholesterol 7 alpha-hydroxylase, change together in parallel directions. It has been suggested that newly synthesized cholesterol may be the preferred substrate for cholesterol 7 alpha...

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Bibliographic Details
Main Authors: WM Pandak, DM Heuman, PB Hylemon, ZR Vlahcevic
Format: Article
Language:English
Published: Elsevier 1990-01-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520427622