Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia

Large-scale mGluR5 network abnormalities linked to epilepsy duration in focal cortical dysplasia

To determine the extent of metabotropic glutamate receptor type 5 (mGluR5) network abnormalities associated with focal cortical dysplasia (FCD), we performed graph theoretical analysis of [11C]ABP688 PET binding potentials (BPND), which allows for quantification of mGluR5 availability. Undirected gr...

Full description

Bibliographic Details
Main Authors:	Jonathan M. DuBois, Sulantha Mathotaarachchi, Olivier G. Rousset, Viviane Sziklas, Jorge Sepulcre, Marie-Christine Guiot, Jeffery A. Hall, Gassan Massarweh, Jean-Paul Soucy, Pedro Rosa-Neto, Eliane Kobayashi
Format:	Article
Language:	English
Published:	Elsevier 2021-01-01
Series:	NeuroImage: Clinical
Subjects:	mGluR5 FCD Epilepsy PET Network
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213158220303892

Similar Items

The Changes in mGluR2 and mGluR7 Expression in Rat Medial Vestibular Nucleus and Flocculus Following Unilateral Labyrinthectomy
by: Wen Zhou, et al.
Published: (2013-11-01)

Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy
by: J. Pitsch, et al.
Published: (2007-06-01)

Activation of a Temporal Memory in Purkinje Cells by the mGluR7 Receptor
by: Fredrik Johansson, et al.
Published: (2015-12-01)

Neuromodulation by mGluRs in Sound Localization Circuits in the Auditory Brainstem
by: Nupur Goel, et al.
Published: (2020-11-01)

The MK2 cascade regulates mGluR-dependent synaptic plasticity and reversal learning
by: Privitera, Lucia, et al.
Published: (2019)

Therapeutic potential of mGluR5 targeting in Alzheimer's disease
by: Anil eKumar, et al.
Published: (2015-06-01)

Reduced mGluR5 Activity Modulates Mitochondrial Function
by: Miguel A. Gonzalez-Lozano, et al.
Published: (2021-06-01)

PET imaging of mGluR5 in Alzheimer’s disease
by: Adam P. Mecca, et al.
Published: (2020-01-01)

Analysis of the Gut Microbiota and Inflammatory Factors in mGluR5-Knockout Mice
by: Guohong Cai, et al.
Published: (2020-04-01)

Differential trafficking of AMPA receptors following activation of NMDA receptors and mGluRs
by: Sanderson Thomas M, et al.
Published: (2011-07-01)

mGluR-dependent synaptic plasticity in drug-seeking.
by: Camilla eBellone, et al.
Published: (2012-08-01)

A positive feedback loop linking enhanced mGluR function and basal calcium in spinocerebellar ataxia type 2
by: Pratap Meera, et al.
Published: (2017-05-01)

Translational concepts of mGluR5 in synaptic diseases of the brain
by: Thomas M Piers, et al.
Published: (2012-11-01)

Loss of mGluR5 in D1 Receptor-Expressing Neurons Improves Stress Coping
by: Luca Zangrandi, et al.
Published: (2021-07-01)

Virtual Screening and Molecular Dynamics Study of Potential Negative Allosteric Modulators of mGluR1 from Chinese Herbs
by: Ludi Jiang, et al.
Published: (2015-07-01)

Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction
by: Hiroki Yasuda, et al.
Published: (2018-10-01)

Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory
by: Sophie Lepannetier, et al.
Published: (2018-09-01)

Characterization of Umami Dry-Cured Ham-Derived Dipeptide Interaction with Metabotropic Glutamate Receptor (mGluR) by Molecular Docking Simulation
by: Alejandro Heres, et al.
Published: (2021-09-01)

mGluR5 Mediates Dihydrotestosterone-Induced Nucleus Accumbens Structural Plasticity, but Not Conditioned Reward
by: Kellie S. Gross, et al.
Published: (2018-11-01)

Activation of the same mGluR5 receptors in the amygdala causes divergent effects on specific versus indiscriminate fear
by: Mohammed Mostafizur Rahman, et al.
Published: (2017-05-01)

Isolation of rat hepatocytes for pharmacological studies on metabotropic glutamate receptor (mGluR) subtype 5: a comparison between collagenase I versus collagenase IV
by: Clarissa Berardo, et al.
Published: (2020-03-01)

In vivo glucose metabolism and glutamate levels in mGluR5 knockout mice: a multimodal neuroimaging study using [18F]FDG microPET and MRS
by: Yo-Han Joo, et al.
Published: (2020-10-01)

Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome
by: Xu Zhao-Hui, et al.
Published: (2012-05-01)

Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism
by: Meera E. Modi, et al.
Published: (2018-06-01)

Brain mGluR5 in Shank3B−/− Mice Studied With in vivo [18F]FPEB PET Imaging and ex vivo Immunoblotting
by: Guohong Cai, et al.
Published: (2019-02-01)

Positive allosteric modulation of mGluR5 accelerates extinction learning but not relearning following methamphetamine self-administration
by: Peter R Kufahl, et al.
Published: (2012-11-01)

Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse model
by: Jesús David Urbano-Gámez, et al.
Published: (2021-05-01)

Investigation on Quantitative Structure Activity Relationships and Pharmacophore Modeling of a Series of mGluR2 Antagonists
by: Chun-Zhi Ai, et al.
Published: (2011-09-01)

Group I mGluR-Mediated Activation of Martinotti Cells Inhibits Local Cortical Circuitry in Human Cortex
by: Tim Kroon, et al.
Published: (2019-07-01)

mGluR1 receptors contribute to non-purinergic slow excitatory transmission to submucosal VIP neurons of guinea-pig ileum
by: Jaime Pei Pei Foong, et al.
Published: (2009-05-01)

mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease
by: Jéssica M. de Souza, et al.
Published: (2020-08-01)

Combination Therapy in Fragile X Syndrome; Possibilities and Pitfalls Illustrated by Targeting the mGluR5 and GABA Pathway Simultaneously
by: Shimriet Zeidler, et al.
Published: (2017-11-01)

The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant <it>FMR1 </it>gene <it>in vitro</it>
by: Tabolacci Elisabetta, et al.
Published: (2012-03-01)

The Drosophila DmGluRA is required for social interaction and memory
by: Brian P. Schoenfeld, et al.
Published: (2013-05-01)

CA1 Neurons Acquire Rett Syndrome Phenotype After Brief Activation of Glutamatergic Receptors: Specific Role of mGluR1/5
by: Saju Balakrishnan, et al.
Published: (2018-10-01)

Rescue of Fmr1KO phenotypes with mGluR5 inhibitors: MRZ-8456 versus AFQ-056
by: Pamela R. Westmark, et al.
Published: (2018-11-01)

Study on Effect of Striatal mGluR2/3 in Alleviating Motor Dysfunction in Rat PD Model Treated by Exercise Therapy
by: Ping Chen, et al.
Published: (2019-10-01)

In Silico Analysis of the Association Relationship between Neuroprotection and Flavors of Traditional Chinese Medicine Based on the mGluRs
by: Xu Zhang, et al.
Published: (2018-01-01)

Modulation of Increased mGluR1 Signaling by RGS8 Protects Purkinje Cells From Dendritic Reduction and Could Be a Common Mechanism in Diverse Forms of Spinocerebellar Ataxia
by: Qin-Wei Wu, et al.
Published: (2021-01-01)

Enhancement of dendritic persistent Na+ currents by mGluR5 leads to an advancement of spike timing with an increase in temporal precision
by: Weonjin Yu, et al.
Published: (2018-11-01)

Cannot write session to /tmp/vufind_sessions/sess_07dv9sa6k3bsg1m8oshau60jcc