GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment.

GABA(A) receptor α subunits differentially contribute to diazepam tolerance after chronic treatment.

Within the GABA(A)-receptor field, two important questions are what molecular mechanisms underlie benzodiazepine tolerance, and whether tolerance can be ascribed to certain GABA(A)-receptor subtypes.We investigated tolerance to acute anxiolytic, hypothermic and sedative effects of diazepam in mice e...

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Bibliographic Details
Main Authors: Christiaan H Vinkers, Ruud van Oorschot, Elsebet Ø Nielsen, James M Cook, Henrik H Hansen, Lucianne Groenink, Berend Olivier, Naheed R Mirza
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3418228?pdf=render

Internet

http://europepmc.org/articles/PMC3418228?pdf=render

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